To demonstrate that lack of regular transcriptional activity, such as the one observed in c-MYC (Figure 1B), MCT4 (Figure 2B), Sestrin-1 (Figure 3B), and SRPX2 (Figure 5B) genes, does not represent a common phenomenon of melanoma cells, and to also validate the integrity of our melanoma RNA/cDNA preparations, next, we examined the expression profiles of a number of genes critically controlling cell metabolism, signaling, survival, and death (apoptosis). The gene discussed is SRPX2; the disease is melanoma.