It seems that the absence of random primers (6-mers) from the RT reaction of BCC and SCC biopsy specimens does not harm our proficiency to detect retained intron incidents, while their (6-mers) presence in the respective protocols for melanoma samples may not cause beneficial results, since the short distance in between the annealed random 6-mers could not allow the generation of long transcripts, like the ones identified for our c-MYC, Sestrin-1, and SRPX2 genes undergoing melanoma-specific intron retention. The gene discussed is SRPX2; the disease is melanoma.