In particular, overexpression of RON (Recepteur d’origine nantais) kinase, L1 cell adhesion molecule (L1CAM), ELF3 (E74-like factor 3), transglutaminase 2 (TG2) (all increased in RanBPM shRNA cells [27]) have all been reported in various tumour types and were shown to be directly implicated in cancer development [28,29,30,31]. The gene discussed is TGM2; the disease is cancer.