Liver to body weight ratios increased in APN KO (APN KO: 5.51 ± 0.277%, n = 21 versus WT: 4.47 ± 0.101%, n = 22; p = 0.0009, Fig 1D), and between groups there was no difference in tumor incidence (Fig 1E). The gene discussed is ANPEP; the disease is neoplasm.