Eighty-four percent (76/90) of the patients were infected with genotype C HBV, while the others were infected with genotype A or B. Male sex, low platelets, low albumin, high alpha fetoprotein (AFP, a tumor marker for HCC), high Fibrosis-4 (FIB-4, an indicator of liver fibrosis) index and HCC history were observed more frequently in the liver cirrhosis group than the inactive carrier and chronic hepatitis groups (Table 1). This evidence concerns the gene AFP and chronic hepatitis.