BRCA1 and neoplasm: We defined 5 HGSC groups (see Methods), representing BRCA1-mutant (clusters 1, 10; n = 36), BRCA2-mutant (cluster 4, n = 19), FBI (clusters 2, 5, 7; n = 50), Intra-Chr (cluster 8, n = 8), and CDK12-like tandem duplicator tumours (cluster 11, n = 5).