BRCA1 and neoplasm: While the original study identified one HRD signature group [2], our analysis here produced two major HRD clusters (1 & 4, n = 34 & 23), roughly defined by tumours with S-Dup and M-Dup (see S10 Fig, S9 Dataset for cluster-signature associations) coupled with loss of BRCA1 (see Fig 6d, S10 Dataset for cluster-annotation associations), and small deletions (Del) coupled with loss of BRCA2, respectively.