The association of BRCA1/2 status with tandem duplication and deletion SV signatures has been reported in breast cancer tumours [13], and was reflected in our analysis of the 560 breast cancer dataset (Fig 5, described above), providing strong evidence for BRCA1-like and BRCA2-like HRD sub-strata crossing tumour types. The gene discussed is BRCA1; the disease is breast carcinoma.