SIRT1 and kidney disorder: As a first step to elucidate the mechanisms underlying this potential protective effect of RAGE knockout, and in light of our results on inflammation and oxidation markers, we focused on SIRT1 (associated with longevity and known to decrease with age (Yuan et al., 2016)) and the AKT/mTor pathway [involved in kidney disease (Kajiwara and Masuda, 2016)].