MTOR and diabetic kidney disease: Indeed, mTOR inhibition is the only therapeutic intervention that leads to enhanced health and life span in all studied models (Johnson, Rabinovitch, & Kaeberlein, 2013; Weichhart, 2018), and downregulation or inhibition of mTORC1 prevents GS, glomerular hypertrophy macrophage infiltration, and other lesions in murine models of diabetic nephropathy (Kajiwara and Masuda, 2016).