Concurrently, and in accordance with previous studies showing that knockout or inhibition of RAGE prevented CML‐ or LPS‐induced reduction in SIRT1 expression (Grossin et al., 2015; Huang et al., 2015), SIRT1 expression was here downregulated in old WT compared with old RAGE−/− mice. The gene discussed is SIRT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.