RASAL2 and breast carcinoma: Ras is one of the key oncogenes; although Ras mutations are comparatively rare in breast cancer, the RasGAP (Ras GTPase Activating Proteins) gene RASAL2 functions as a tumor suppressor.34 Furthermore, we found enrichment evidence for sodium bicarbonate symporter activity, which enables the transfer of a solute or solutes from one side of a membrane to the other and has a central role in pH regulation.