ALDH6A1 and ALDH6A1 were significantly upregulated in metastatic prostate cancer and could be used to predict the survival of patients.(Cho et al., 2018) A previous study showed that HADH knockdown can promote tumor cell migration and invasion by activing Akt signaling pathway.(Shen et al., 2017) Evidence indicated that ACADSB was also markedly downregulated in HCC cell lines.(Nwosu et al., 2018) However, no studies have reported the effects of hub genes on the initiation and progression of KIRC. This evidence concerns the gene ACADSB and hepatocellular carcinoma.