NGFR and obesity due to melanocortin 4 receptor deficiency: PWS4 possessed a single missense variant in the autosomal recessive or dominant NTRK1 gene encoding a nerve growth factor receptor when disturbed leads to congenital insensitivity to pain with anhidrosis, while the second gene (VPS13B) causes Cohen syndrome #216550 with intellectual disability and obesity (Online Mendelian Inheritance in Man, 2018).