SP1 and cancer: MMP‐2 is a sort of zinc‐dependent endopeptidases, which can regulate various cell behaviors such as tumor initiation and growth by modulating cell proliferation, apoptosis and angiogenesis.97, 98 The SNP (rs243865), located in the promoter region of the MMP‐2, disrupts an Sp1‐type promoter site (CCACC box) and then affects MMP‐2 expression or activity, which was considered to be associated with development of cancer condition.99 Our review showed that the SNP (rs243865) was rates as strong evidence of association with EC risk (OR = 0.67, 95% CI = 0.55‐0.80) under dominant model.