Cumulative evidence were downgraded from strong to moderate for IL‐18 −607C>A, MMP1 rs1799750, SLC52A3 rs13042395 and MDM2 rs2279744 in EC, and TNF‐α rs1800629, C20orf54 rs13042395, microRNA124 rs531564 in ESCC, from moderate to weak for GSTT1 null/present, XRCC1 rs1799782, Hsa‐mir rs3746444, hOGG1 rs1052133, STK15 rs2273535 in EC, and microRNA‐34b/c rs4938723, NAT2 rapid/slow in ESCC, based on FPRP >0.2. This evidence concerns the gene MDM2 and esophageal squamous cell carcinoma.