EGF, located on chromosome 4q25‐q27,92, 93 participates in the process of proliferation and differentiation of cells94 and promotes gene transcription when EGF binds to its receptor.95 Quiet a few studies have identified the G allele promoted the EGF protein expression when EGF binds to its receptor which could interfering DNA folding and further increased susceptibility of a range of human cancers.96 Our review showed that the G allele of EGF +61A>G (rs4444903) polymorphism was rated as strong evidence of association with 1.38‐fold increased risk of EC based on 1713 sample size. This evidence concerns the gene EGF and cancer.