Indeed, it has been reported that magnolol upregulates apoptotic proteins like caspases‐8,9, cleaved caspase‐3, PARP and reciprocally downregulate anti‐apoptotic proteins such as Bcl‐2 and Mcl‐1.19, 24 Moreover, PI3K/Akt signaling is known to up‐regulate anti‐apoptotic proteins like Bcl‐2 and Mcl‐1 thus promoting cancer cell survival.29 Therefore, it can be inferred that magnolol‐induced downregulation of PI3K/Akt signaling might also deregulate the balance of anti‐apoptotic and apoptotic proteins resulting in melanoma cell death. This evidence concerns the gene MCL1 and cancer.