Another study demonstrated a potent antitumor effect of honokiol bis‐dichloroacetate in vemurafenib‐resistant melanoma in vivo.26 Consistently, a recent study showed a synergistic effect of honokiol and MAPK inhibitor in BRAFmt melanoma cells by disrupting mitochondrial electron transport chain.27 Since magnolol is structurally similar to honokiol, it is expected to have a similar effect on the BRAF inhibitor resistance melanoma cells; however, this requires further investigation. This evidence concerns the gene BRAF and melanoma.