H2AX and lung cancer: Magnolol was found to induce DNA fragmentation in a dose‐dependent manner in non‐small cell lung cancer cells.19 Along this line, several studies revealed that ɣ‐H2AX and the repressive mark, H3K9me3, deposited at DNA damage sites are considered as markers for the DNA damage response.20 Likewise, we have observed an increase of the repressive histone mark H3K9me3 upon magnolol treatment accompanying by upregulation of ɣ‐H2AX.