An earlier study reported that magnolol downregulates ERK and Akt phosphorylation, albeit at a higher concentration, in non‐small cell lung cancer cells.19 However, magnolol did not induce any alteration of the pathways in BRAF/NRAS wild‐type melanoma cells and keratinocytes at low concentrations suggestive that magnolol‐induced downregulation of survival pathways might be dependent on the mutation status of cancer cells. The gene discussed is AKT1; the disease is melanoma.