demonstrated that MARCH1 silencing by siRNA suppressed cell development and progression via the down‐regulation of the Wnt/β‐catenin pathway in ovarian cancer.13 To explain how down‐regulated MARCH1 inhibited HCC cell proliferation, migration and invasion and promoted cell apoptosis, we explored the underlying molecular changes downstream of the MARCH1 perturbation. This evidence concerns the gene MARCHF1 and hepatocellular carcinoma.