MARCHF1 and hepatocellular carcinoma: MARCH1 regulated INSRβ Lys1079, which is a potential substrate to regulate surface INSRb expression, and MARCH1 expression was regulated through a canonical FOXO1‐mediated mechanism.32 Recent studies have reported that anti‐apoptotic Mcl‐1 and Bcl‐2 were often overexpressed and played pivotal roles in malignancies, including in HCC.