Our data are consistent with earlier studies demonstrating that tumour ADC increase was associated with the induction of necrotic and apoptotic cell death.39 In addition, a previous study reported that ADC values of differentiated pancreatic ductal adenocarcinoma (PDAC) were higher than those of non‐differentiated PDAC xenografts.40 Therefore, our findings depicted that MARCH1 plays a promotional role in the development and progression of HCC in vitro and in vivo. This evidence concerns the gene MARCHF1 and pancreatic ductal adenocarcinoma.