Unexpectedly, the decrease rate of APP and ADAM10 has no difference between the experiment group and control group in tumour cell treatment with actinomycin D which was used to inhibit de novo transcription.13 These data showed that the effect of HuR‐regulated APP and ADAM10 levels was not through stabilizing APP and ADAM10 mRNA stability. This evidence concerns the gene ELAVL1 and neoplasm.