Furthermore, the phosphorylation of Erk1/2 was reduced in tumour cells treated with EGCG, which was consistent with the reported that EGCG inhibits cognitive dysfunction through inhibition of ERK pathway.16 These results indicated that EGCG induced tumour cells apoptosis through the EGCG‐HuR‐ERK‐APP/ADAM10 pathway, rather than regulating HuR to stabilize the stability of APP and ADAM10 mRNA. Here, ADAM10 is linked to neoplasm.