Amyloid precursor protein (APP) is a member of the APP family of proteins, and different enzymatic processing leads to the production of several derivatives that are shown to have distinct biological functions.10 We previously found that EGCG induced neuroblastoma apoptosis via inhibition of amyloid precursor protein.6 In this study, we first demonstrated that EGCG induced HepG2 and PC12 apoptosis and regulated apoptosis‐related proteins Bax and Bcl‐2 expression. Here, APP is linked to neuroblastoma.