P53 is highly expressed under diabetic condition, contributing to the pathogenesis of DM,34, 35 diabetic cardiomyopathy,36 nephropathy22, 37 and peripheral artery disease.38 Here we report the pathogenic effect of P53 on diabetic aortic endothelial dysfunction, with miR‐34a to be the mediator. Here, TP53 is linked to peripheral arterial disease.