Previous studies demonstrated that miR‐19a regulated the cell proliferation and apoptosis by targeting PTEN in osteosarcoma stem cells and hepatocellular carcinoma.12, 13 Moreover, we found that the expression levels of PTEN mRNA were obviously up‐regulated when overexpressed SLC25A5‐AS1 in SGC‐7901 and BGC‐823 cells (Figure 7A,B). The gene discussed is SLC25A5; the disease is osteosarcoma.