In addition, miR‐19a also plays critical roles through activating the PI3K/AKT pathway in GC.14, 15 Thus, we explored whether SLC25A5‐AS1 regulating cell proliferation, cell cycle and apoptosis were directly interacted with miR‐19a‐3p via the PTEN/PI3K/AKT pathway. The gene discussed is AKT1; the disease is gastric cancer.