Activation of caspase‐7 is involved in the execution phase of apoptosis.21 Previous studies have demonstrated that caspase‐7 is deficient in CRC.22 PARP1 is a poly‐ADP ribose polymerase that participates in DNA repair and apoptosis and can be cleaved by caspase‐7 and caspase‐3. The gene discussed is PARP1; the disease is colorectal carcinoma.