SQSTM1 and colorectal carcinoma: In addition, the monolayer scratch healing assays showed that the overexpression of p62 significantly increased the migration ability of HCT116 cells (Figure 3C, P < 0.05), while knockdown of p62 in SW480 cells suppressed the migration capacity (Figure 3D, P < 0.01), indicating that p62 enhances CRC invasion and migration abilities.