Cyclin D1 responds to mitotic growth factors and activates its homologous CDK in the G1 phase.25 Our study shows that the expression levels of c‐Myc, CKD2 and cyclinD1 proteins were increased in p62‐overexpression HCT116 cells, while their expression was decreased in p62‐knowdown SW480 cells, demonstrating that p62 also promotes cell proliferation in CRC. Here, SQSTM1 is linked to colorectal carcinoma.