Histological analysis of the tumour metastasis in the lungs revealed that only 20% (1/5) of the mice bearing p62‐knockdown SW480 cells showed lung metastasis after 2 months of induction, while 100% (5/5) of the mice bearing SW480‐EV cells showed lung metastasis (Figure 4C,D). The gene discussed is SQSTM1; the disease is neoplasm.