TNFSF10 and cancer: Here, we adopted the CA approach to predict the outcome of HT1080 under three experimental conditions; (i) untreated, (ii) treatment with TRAIL only, and (ii) treatment with TRAIL and BIS I. As details on cancer cell proliferation and self-organizing response after any drug treatment is scanty, we wanted to investigate whether (i) simple rules, such as CA rules, can be used to track cancer cell proliferation and, (ii) models developed using such rules can be experimentally tested.