TNFSF10 and cancer: Although the rules, owing to its abstractness or oversimplification, may not be sufficient to model cancer self-organization successfully, nevertheless, they can generate complex self-organizing spatiotemporal patterns that have been explored in numerous scientific fields.20 We simulated to see how the automata will evolve in a simulated dish for three experimental conditions: (i) untreated HT1080 (WT), (ii) HT1080 treated with TRAIL (TRAIL), and (iii) HT1080 treated with TRAIL and PKC inhibitor BIS I (TR + BIS) based on the actual cell numbers after initial treatment.