In unselected patients, BRCA1 and BRCA2 mutations are reported in ranges of 0.3%–13% and 0.75–7.41%, respectively, while in high-risk/hereditary/familiar breast cancer patients, mutations in BRCA1 and BRCA2 were reported in 0.9%–16.6% and 0.49%–18.2%, respectively (Table 2). The gene discussed is BRCA1; the disease is breast cancer.