On a similar note, a prospective cohort of BC patients undergoing neoadjuvant treatment found that poor survival in young patients could be explained by the worse prognosis in the most prevalent hormone receptor-positive/HER2-negative subgroup, possibly due to a greater proportion of Luminal B tumours, tamoxifen resistance or poor adherence to hormonal treatment [19]. The gene discussed is NR4A1; the disease is neoplasm.