In BRAF-(V600E)-mutated melanoma, pharmacological Cu sequestration with a clinically used copper chelator, ammonium tetrathiomolybdate (TTM) inhibits MEK1/2 kinase activity and reduces mutant BRAF-driven growth in melanoma cell lines resistant to BRAF or MEK1/2 inhibitor [3]. Here, MAP2K1 is linked to melanoma.