TA-4, TA-5, TA-7, TA-10, BC-1, BC-2, BC-3, SA-5, SA-6, SA-7, SA-8, SA-10, SA-12, SS-5, SS-7, SS-13,FHV-1, FHV-4, FHV-6, FHV-9, FHV-10, FHV-11, FHV-12, FHV-19, and FHV-24 are effective compounds in LZTB that directly intervene with RA pathways, and 13 genes are involved: CCL2, CCL3, CCL5, FOS, IFNG, IL1B, ITGAL, ITGB2, JUN, TLR4, TNF, TNFSF11, and VEGFA. This evidence concerns the gene CCL2 and rheumatoid arthritis.