Mutations in the PRSS1 (serine protease 1) gene encoding human cationic trypsinogen have been found in families with autosomal dominant hereditary pancreatitis and in sporadic cases without a family history (Whitcomb et al., 1996; Németh and Sahin-Tóth, 2014). The gene discussed is PRSS1; the disease is hereditary chronic pancreatitis.