Depsite the unexpected decrease of CD126 expression after miR-124 inhibition, the effect on downregulation of CD126 expression or inhibition of STAT3 activity or IL-17 production by VD seen in iNC group was indeed diminished by miR-124 inhibition, which clearly demonstrated that suppression of Th17 cells by VD was associated with miR-124 mediated inhibition of IL-6 signaling. This evidence concerns the gene IL6 and sexually transmitted disease.