In colorectal cancer, VEGF secretion by colorectal carcinoma cells stimulates tumor-associated macrophages (TAMs) to produce chemokine (C-X-C motif) ligand 1 (CXCL1), which recruits C-X-C motif chemokine receptor 2 (CXCR2)+ MDSCs to the liver tissue. This evidence concerns the gene CXCL1 and colorectal cancer.