In pancreatic ductal adenocarcinoma-bearing mice, a mAb targeting pancreatic ductal adenocarcinoma-associated antigen α-enolase (ENO1) inhibited in vivo infiltration of MDSCs into the tumor microenvironment and attenuated their restraint of the effector T cell response (124). Here, ENO1 is linked to pancreatic ductal adenocarcinoma.