PTEN and neoplasm: PTEN, BRCA1, and BRCA2 proteins play an important role in resisting the growth of BREAST cancer (Barnes-Kedar et al., 2018; El Botty et al., 2018; Sirisena et al., 2018), while PI3K and CCND1 proteins could improve the growth of BREAST cancer (Ortiz et al., 2017; Sirisena et al., 2018).