Moreover, other than stimulating the release of IL-6, exercise training generates an appropriate environment making the IL-6 effect distinctly anti-inflammatory: for instance, aerobic training reduces the expression of TNF-α and IL-1α by mononuclear cells and induces IL-4, IL-10, and TGF-β1 in subjects at high-risks of heart disease (76). The gene discussed is IL6; the disease is heart disorder.