Therefore, it is speculated that additional Xq copies may trigger escape-inactivated gene overexpression, including diabetes-related genes such as islet cell antigen (ICA), C-reactive protein (CRP), insulin-like growth factor-II (IGFI-II), and other genes related to the normal physiological functions of islet cells (GLIS3, KLF11) (12). This evidence concerns the gene CRP and diabetes mellitus.