BRD2 and neoplasm: Both:•Infertile•Gonadal stromal tumors•Increased serum FSH levels•Die from cachexia-like symptomsMales:•Testicular enlargement/ hemorrhage•Decrease in number of Leydig cells•Decreased spermatogenesis proportional to tumor sizeFemales:•Ovarian hemorrhage•Decreased folliculogenesis proportional to tumor size