SHANK3 and nervous system disorder: We also include some original data that provides evidence indicating that SHANK3 is under post-transcriptional control by an inducible NF-kB-regulated microRNA-34a in the temporal lobe neocortex, and adds to the growing list of pathological genetic mechanisms and cardiovascular and neurological disease-relevant messenger RNAs (mRNAs) targeted by the CNS-abundant miRNA-34a [see below;(15–18)].