SLC8A1 and type 2 diabetes mellitus: Indeed, overall, animal models of type 2 diabetes present a reduced Na+/Ca2+ exchanger activity, and depressed Ca2+ transient linked to downregulation of Ca2+ channels, RyRs, and reduced SERCA activity (Netticadan et al., 2001; Zhong et al., 2001; Abe et al., 2002; Belke et al., 2004; Pereira et al., 2006b; Boudina and Abel, 2010).