Panigrahy and colleagues showed that CYP2CJ and CYP2C8 overexpressing mice and Ephx2-/- mice had enhanced corneal and neonatal retinal vascularization (Panigrahy et al., 2013) and enhanced tumor dependent corneal angiogenesis (Panigrahy et al., 2012). The gene discussed is EPHX2; the disease is neoplasm.