PNS orally taken at 100 mg/kg significantly reversed thrombin-induced hyper-coagulate state in rats which was accompanied by PPAR-γ protein and mRNA up-regulation in rat lung, which indicated that PNS might play a preventive role in the process of thrombosis, especially in DVT and pulmonary embolism (Shen et al., 2017). The gene discussed is PPARG; the disease is pulmonary embolism.