D1-R activation increases NMDA and GABA conductance, and a recent clinical study of intravenous agonist dihydrexidine showed enhanced verbal working memory in schizotypal personality disorder, albeit with side-effects including sedation and cardio-vascular effects (Rosell et al., 2015; Arnsten et al., 2017). This evidence concerns the gene DRD1 and schizotypal personality disorder.