In addition, a previous study found that IL-10 could enhance initial demyelination via inhibiting the production of interferon γ (IFN-γ) (Puntambekar et al., 2015) while another study suggested that the inflammatory score composited of IL-10, TNF-α, IL-1β, and IL-23 was negatively associated with lower FA within periventricular WM in Alzheimer’s disease (Swardfager et al., 2017). This evidence concerns the gene IL1B and early-onset autosomal dominant Alzheimer disease.