It was also noted that the dysregulation of systemic IL-10 was also related to the negative and general symptoms of schizophrenia (Xiu et al., 2014; Kapelski et al., 2016), as well as cognitive function (Xiu et al., 2016), indicating a link between systemic IL-10, WM integrity and clinical symptoms in schizophrenia. This evidence concerns the gene IL10 and schizophrenia.