Patients with LRE was significantly older (mean age 61 vs. 52 years; p < 0.001), had the higher proportion of diabetes (26.5% vs. 7.0%; p < 0.001) and the higher prothrombin time (mean international normalized ratio 0.9 vs. 0,8; p = 0.036), compared to those without HCC. This evidence concerns the gene F2 and diabetes mellitus.