In addition, 5 SNPs (IL1B, rs16944: P < 0.001; IL6, rs1800795: P < 0.001; rs2069837: P < 0.001; TNF, rs1800629: P = 0.001; rs361525: P < 0.001) within the three genes were associated with smoking TB. This evidence concerns the gene IL6 and tuberculosis.