Other pathways were Rac Signalling, which is involved in the regulation of insulin-stimulated glucose uptake58; RhoA Signalling, pathway that has been implicated in the pathogenesis of diabetes59; and Leptin Signalling in Obesity, since leptin is a regulator of glycaemic control60. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.