Some of the statistically significant pathways were related to insulin and glucose, such as Protein Kinase A Signalling, Sirtuin Signalling Pathway, G-Protein Coupled Receptor Signalling, Rac Signalling, Mature Onset Diabetes of Young (MODY) Signalling, RhoA Signalling, and Leptin Signalling in Obesity. The gene discussed is RHOA; the disease is obesity due to melanocortin 4 receptor deficiency.