This finding is to some extent in line with the result in the study by Ramanan et al. 3, showing faster cognitive decline, measured as difference in verbal episodic memory performance, among carriers of the rare alleles of the SNP rs12053868 (r2 = 0.4 with rs37739976) in APOE ɛ4 individuals. The gene discussed is APOE; the disease is Mental deterioration.