EZH2 and neoplasm: Methyltransferase such as DNA methyltransferases (DNMTs), demethylase such as Ten eleven translocation (TET) enzymes, histone-modifying enzymes such as histone lysine-specific demethylase 1 (LSD1)45, and zeste homolog 2(EZH2)46 are important regulators associated with epigenetic silencing of tumor suppressor genes.