Treatment with EO led to significant downregulation of Caspase-3 gene (60% decrease; AMD untreated: 1 ± 0.063 a.u.; AMD EO-treated: 0.400 ± 0.112 a.u.; p=0.008; n=5) (Figure 4A), suggesting that EO reduces caspase-3-mediated apoptosis in AMD cybrids. Here, CASP3 is linked to age-related macular degeneration.