SOD2 and age-related macular degeneration: Furthermore, EO-treated AMD cybrids showed upregulation of SOD2 gene compared to their untreated counterparts (357.3% increase; AMD untreated: 1 ± 0.133 a.u.; AMD EO-treated: 4.573 ± 0.533 a.u.; p=0.029; n=4) (Figure 5D).