Moreover, EO-treated AMD cybrids showed upregulation of the PGC-1α gene (1498% increase; AMD untreated: 1 ± 0.277 a.u.; AMD EO-treated: 15.98 ± 1.589 a.u.; p=0.029; n=4) (Figure 6B). Here, PPARGC1A is linked to age-related macular degeneration.