Moreover, upregulation of the mitochondria derived peptide (MDP)-coding MT-RNR2 gene (3006% increase; AMD untreated: 1± 0.231 a.u.; AMD EO-treated: 31.06 ± 11.93 a.u.; p=0.008; n=5) (Figure 4B) was observed in EO-treated AMD cybrids compared to untreated cells, suggesting higher MDP production as a result of EO treatment. This evidence concerns the gene MT-RNR2 and age-related macular degeneration.