We observed significant downregulation of VEGF gene in EO-treated AMD cybrids compared to untreated cybrids (64.7% decrease; AMD untreated: 1 ± 0.066 a.u.; AMD EO-treated: 0.353 ± 0.132 a.u.; p=0.029; n=4) (Figure 7A). The gene discussed is VEGFA; the disease is age-related macular degeneration.