Given that BCL-3 is overexpressed in a subset of CRCs and is linked to poor prognosis (Puvvada et al., 2010), and that the Wnt pathway is deregulated in the vast majority of colorectal tumours (Segditsas and Tomlinson, 2006), the aim of this study was to investigate the role of the NF-κB co-regulator BCL-3 in β-catenin/TCF-mediated signalling in CRC cells. This evidence concerns the gene NFKB1 and colorectal neoplasm.