APC and colorectal cancer: Unsurprisingly, given its importance in gut development, maintenance and homeostasis (Clevers and Nusse, 2012), deregulation of Wnt signalling is an initiating factor in colorectal tumorigenesis; with adenomatous polyposis coli (APC) mutation being the most frequent event in colorectal cancers (CRCs) (Segditsas and Tomlinson, 2006).