Considering the importance of Wnt/β-catenin and NF-κB crosstalk in cellular de-differentiation and tumour initiation in the intestine (Schwitalla et al., 2013), surprisingly there have been no studies exploring the role of the NF-κB co-regulator BCL-3 in Wnt signalling in CRC. The gene discussed is BCL3; the disease is neoplasm.