Importantly, we show that BCL-3 suppression can downregulate β-catenin signalling in cells expressing mutant APC (the most common mutation in CRCs) and mutant β-catenin itself (in addition to cells with non-mutated Wnt components), which suggests that targeting BCL-3 would reduce β-catenin signalling in colorectal tumours. The gene discussed is BCL3; the disease is colorectal neoplasm.