Familial DCM counts for more that 50% of all cases reported of DCM, and most of them are associated with genetic variations of single genes including, ACTC1, RBM20, MYBPC3, MYH6, MYH7, TNNT2, TPM1, SCN5A, FHOD3, SLC39A8, MLIP, ALPK3, or BAG3 [2,22]. The gene discussed is TNNT2; the disease is familial dilated cardiomyopathy.