HSPA8 and familial dilated cardiomyopathy: Functional studies revealed that some forms of familial dilated cardiomyopathies (FDCMs) are related to BAG3 mutations with impaired Z-disc assembly and sensitivity to stress-induced apoptosis [3] proposing that myofibrillar integrity under mechanical stress is maintained by the complex BAG3–Hsc70, since Hsc70 regulates the chaperone-dependent E3 ligase CHIP [4,5].