BAG3 and familial dilated cardiomyopathy: In DCM BAG3-mutation carriers, the levels of mir-182-5p resulted significantly elevated respect to asymptomatic patients, and correlated with LVEF both in men and women, suggesting that lack of mir-182-5p expression may be related with the antiapoptotic effect of BAG3 in the heart, as others reported in mice overexpressing BAG3, and subjected to myocardial infarction, showing improved left ventricular function, and reduced hypoxia-induced cardiomyocyte apoptosis [37].