To first determine the miRNA profile associated to BAG3 mutation, the analysis of 1759 circulating miRNAs was performed in BAG3 mutant carriers (BAG3+/DCM+ and BAG3+/DCM-) and BAG3 wild-type individuals (BAG-/DCM+ and BAG3-/DCM-). This evidence concerns the gene BAG3 and familial dilated cardiomyopathy.