Next, we verified that zoledronic acid significantly decreased the phosphorylation of Erk1/2 and Akt, but had almost no effects on the expression of total Ekr1/2 and Akt as well as on PI3K, JNK, p38, pho-JNK, and pho-p38 in cervical cancer cells derived CSCs. This evidence concerns the gene MAPK8 and cervical carcinoma.