Alzheimer’s disease (AD) may be described as a biological continuum that includes the hallmark pathological processes of amyloid-beta (Aβ) dysmetabolism, formation of amyloid deposits (A), neurofibrillary tangles (T), neurodegeneration (N), determined by measuring cerebrospinal fluid (CSF) levels of Aβ42, phosphorylated tau (P-tau), and total tau (T-tau) respectively. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.