Notably, loss of LPCAT1 inhibited the expression of p-AKT and MYC in vitro (Fig. 5b) and in vivo (Fig. 5c), suggesting that the PI3K/AKT/MYC pathway was involved in the inhibition of NSCLC metastasis caused by LPCAT1 reduction. The gene discussed is MYC; the disease is non-small cell lung carcinoma.