SLC40A1 and cancer: Chifman and coworkers developed an ODE-based model for iron dysregulation in cancer cells in which the roles of the IRP-based regulation, the iron storage protein ferritin, the iron export protein ferroportin, the labile iron pool, reactive oxygen species, and the cancer-associated Ras protein were emphasized [13], as well as a logical-rule-based mathematical model of iron homeostasis in healthy mammalian cells [14].