One example of bypassing signaling activation is acquired mesenchymal epithelial transition factor receptor (Met) gene amplification [14], causing c-Met amplification to circumvent the inhibited EGFR phosphorylation kinase pathway and activate downstream signal transduction, such as the PI3K/AKT pathway, thus developing resistance to EGFR-TKI and facilitating tumor cell proliferation. Here, EGFR is linked to neoplasm.