MTOR and neoplasm: Also, three cytoskeleton-associated proteins, namely: d) TBB2B, which is a major component of microtubules [123], e) AKAP1, shown to support mTOR-dependent tumor growth in breast cancer cells [111] and f) SRBS1, an adapter protein which regulates the assembly of kinase signaling complexes bound to the actin cytoskeleton.