But serum klotho was not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease (HR((95%CI) = 1.002(0.986–1.018), p = 0.776) or with cerebral infarction (HR(95%CI) = 1.005(0.987–1.023), p = 0.576). This evidence concerns the gene KL and cerebral infarction.