Rheumatoid arthritis-specific risk factors (RA disease more than 10 years, presence of joint erosions, joint space narrowing, extra-articular manifestations, BMI < 20, Rheumatoid Factor (RF) or anti-citrullinated peptide antibodies (ACPA) positivity, erythrocyte sedimentation rate (ESR) ≥ 42 mm/h. Here, PRTN3 is linked to rheumatoid arthritis.